Activity Description

Despite advances in generalized myasthenia gravis (gMG), muscle-specific tyrosine kinase (MuSK+), low density lipoprotein receptor related protein 4 (LRP4+), and triple-seronegative MG remain underrecognized and are often managed using paradigms derived from acetylcholine receptor (AChR)-positive disease. Neurologists, neuromuscular specialists, nurse practitioners (NPs), and physician associates (PAs) who evaluate adults with suspected or confirmed gMG need education to improve subtype appropriate diagnostic evaluation, interpret serologic and electrodiagnostic results, apply mechanism-informed treatment strategies, and distinguish current regulatory labeling from evidence supported and investigational approaches. Education should also strengthen clinicians' ability to establish individualized treatment goals and longitudinal monitoring using validated measures that capture bulbar and respiratory symptoms, fatigue, treatment burden, and quality of life. Addressing these learning gaps will support earlier recognition of non-AChR MG subtypes, more appropriate therapeutic decision-making, and more patient-centered, coordinated care for these historically underserved populations.

In this CME Outfitters Grand Rounds initiative, expert faculty will guide learners in applying diagnostic and treatment strategies for these subtypes, clarifying interprofessional roles, and using patient centered goals and validated measures to support coordinated monitoring and care over time.

Target Audience

Neurologists, neuromuscular specialists, nurse practitioners (NPs), and physician associates (PAs) who evaluate adults with suspected or confirmed gMG; interpret serologic and electrodiagnostic testing; select immunotherapies; and monitor longitudinal response and treatment burden in antibody-defined and seronegative MG populations.

Learning Objectives

At the conclusion of this activity, learners will be able to better:

• Identify appropriate diagnostic testing strategies to detect MuSK+, LRP4+, and triple-seronegative MG
• Select treatment strategies aligned with disease mechanism, available evidence, and current therapeutic context in MuSK+, LRP4+, and triple-seronegative MG
• Outline the roles and responsibilities of interprofessional healthcare team members in individualized treatment goals and validated outcome measures used to monitor response in patients with MuSK+, LRP4+, and triple-seronegative MG

Host a Grand Rounds at Your Facility

There is no fee to host a live or virtual Grand Rounds session, and complimentary meeting materials are provided. We take care of the heavy lifting—at no cost to your facility!

Programs are thoughtfully designed to address the unique needs of your interprofessional team and provides valuable CE credit at no cost to you. Interested in hosting a live or virtual session? Complete the form below or contact us at grandrounds@knowfully.com.

Credit Information

Jointly Accredited Provider

In support of improving patient care, CME Outfitters, LLC, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

IPCE

This activity was planned by and for the healthcare team, and learners will receive 1.0 Interprofessional Continuing Education Credit for learning and change.

Physicians (ACCME)

CME Outfitters, LLC, designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Nurses (ANCC)

This activity is designated for 1.00 contact hours.
California Residents: Provider approved by the California Board of Registered Nursing, Provider # CEP 15510, for 1.00 Contact Hours.

Physician Assistants (AAPA)

CME Outfitters, LLC, has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 1.00 AAPA Category 1 CME credits. PAs should only claim credit commensurate with the extent of their participation.

Royal College MOC

Through an agreement between the Accreditation Council for Continuing Medical Education and the Royal College of Physicians and Surgeons of Canada, medical practitioners participating in the Royal College MOC Program may record completion of accredited activities registered under the ACCME’s “CME in Support of MOC” program in Section 3 of the Royal College’s MOC Program.

MIPS Improvement Activity

Completion of this accredited CME activity meets the expectations of an Accredited Safety or Quality Improvement Program (IA_PSPA_28) for the Merit-based Incentive Payment Program (MIPS). Clinicians should submit their improvement activities by attestation via the CMS Quality Payment Program website.

Certificate of Participation

This activity was certified for a maximum of 1.00 AMA PRA Category 1 Credit(s)™. This activity was planned by and for the healthcare team, and learners will receive 1.0 Interprofessional Continuing Education Credit for learning and change.

ABIM MOC

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.00 MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.